“International Medical Service in Egypt.”

CK- MB Mass Assay

Acute myocardial infarction remains a leading cause of morbidity and mortality worldwide. The severity of an MI depends on three factors: the level of the occlusion in the coronary artery, the length of time of the occlusion, and the presence or absence of collateral circulation. Timely diagnosis is crucial for proper patient care. Once a patient's clinical picture raises a suspicion of MI, several confirmatory tests can be performed rapidly. These tests include electrocardiography, blood testing, and echocardiography.

CK, CK-MB isoenzyme and Troponin are the blood markers most often used for diagnosis of AMI. A typical rise and fall of their levels occur following AMI. CK-MB activity has long been measured using an immunochemical technique employing an anti M subunit inhibiting antibody. However this method is subject to interferences with macro CK, mitochondrial CK, or CK BB. CK BB is absent from healthy serum, but may be present in sera from patients suffering from head injuries, brain infarcts, critically ill patients. Presence of CK BB in serum thus causes a false elevation of CK-MB activity results, which may even exceed total CK values.

CK-MB activity assays have largely been replaced worldwide by a CK-MB mass assay, which is specific for the MB isoenzyme, and is not subject to interference from CK-BB.

CK-MB mass assay is now available in Alpha Laboratories. A single serum sample can be used for the assay of both CK-MB mass and Troponin I, on the Architect i 2000 SR. Results can be delivered within 2 hours of sample collection.

 
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